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J Shahrekord Univ Med Sci. 2023;25(1): 30-38.
doi: 10.34172/jsums.2023.726
  Abstract View: 73
  PDF Download: 28

Original Article

The effect of resistance training on blood pressure, apelin, ANP, PON1, adiponectin, H2O2, and ET-1 in hypertensive men

Behrouz Baghaiee 1* ORCID logo, Nasibeh Dolatabadi Farahani 2 ORCID logo, Linda S Pescatello 3 ORCID logo, Elshan Davaran Hagh 4 ORCID logo, Khadijeh Ebrahimi 5 ORCID logo

1 Department of Physical Education and Sport Science, Jolfa Branch, Islamic Azad University, Jolfa, Iran
2 Department of Physical Education and Sport Science, Damghan Branch, Islamic Azad University, Damghan, Iran
3 Department of Kinesiology, College of Agriculture, Health and Natural Resources, University of Connecticut, Connecticut, USA
4 Shabestar Branch, Islamic Azad University, Shabestar, Iran
5 Department of Physical Education and Sport Science, Marand Branch, Islamic Azad University, Marand, Iran
*Corresponding Author: Corresponding Author: Behrouz Baghaiee, Email: behrouz_phsport@yahoo.com, Email: behrouz_phsport@yaoo.com

Abstract

Background and aims: Primary hypertension, an unexplained increase in blood pressure (BP), accounts for 90% of the cases of hypertension and remains a critical public health challenge. This study aimed to investigate the effects of 12-week resistance training (RT) on some vasodilators and vasoconstrictors in hypertensive men.

Methods: This is a semi-experimental study. A total of 40 middle-aged men (45.3±3.2 years) with moderate hypertension (systolic BP [SBP] 140.5±0.3 and diastolic BP [DBP] 90.7±0.0 mm Hg) were randomly divided into the RT (n=20) and non-exercise control (n=20) groups. The 12-week dynamic RT program was performed at an intensity of 80% of one repetition maximum for 3 days per week (3 sets of 8 repetitions/3 days a week). Blood samples were taken from both groups at baseline and weeks 4, 8, and 12.

Results: SBP and DBP decreased by -8.19±2.46 mm Hg (P=0.039) and -1.19±0.02 mm Hg (P=0.033) from baseline at week 12 in the RT group, respectively, compared to the control group (SBP; 8.22±2.49, P=0.04; DBP; -1.19±0.03, P=0.032). Adiponectin, apelin, atrial natriuretic peptide (ANP), and paraoxonase-1 (PON-1) serum levels increased from baseline at weeks 8 (P=0.01) and 12 (P=0.01), while endothelin-1 (ET-1) and H2 O2 decreased from baseline at weeks 8 (P=0.01) and 12 (P=0.01) in the RT in comparison to the control group.

Conclusion: Overall, 12-week RT led to an increase in apelin, ANP, PON-1, and adiponectin. Increasing these markers reduces H2 O2 and ET-1, thus decreasing SBP and DBP in hypertensive men.

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Submitted: 20 Jun 2022
Revision: 20 Sep 2022
Accepted: 20 Sep 2022
ePublished: 21 Nov 2022
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