J Shahrekord Univ Med Sci. 2023;25(4): 201-203.
doi: 10.34172/jsums.663
  Abstract View: 247
  PDF Download: 226

Case Report

The effect of lithium on clozapine-induced neutropenia reduction in refractory schizoaffective disorder

Mehri Rezaei Kheirabadi 1 ORCID logo, Fatemeh Naderi 2 ORCID logo, Ahmad Karami 3* ORCID logo

1 Department of Psychology, Faculty of Educational Sciences and Psychology, University of Isfahan, Isfahan, Iran
2 Department of Pediatric Dentistry, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Department of Psychiatry, School of Medicine, Hajar Hospital, Shahrekord University of Medical Sciences, Shahrekord, Iran
*Corresponding Author: Ahmad Karami, Email: Karami.a@skumsc.ir


Resistant schizoaffective disorder has persistent psychotic symptoms and intermittent mood swings. A satisfying method for treating these patients is the use of the antipsychotic drug clozapine, but its use is limited due to significant side effects such as leukopenia and neutropenia. Lithium carbonate is another psychiatric drug that reduces these side effects. We hypothesized that lithium, along with clozapine, in addition to controlling side effects, could have a dual effect on mood episodes in schizoaffective disorder, and used it in a chronic case. The patient was a 48-year-old man with a 20-year history of the disease. Therefore, the use of lithium along with clozapine is recommended in refractory schizoaffective patients.
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Abstract View: 248

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Submitted: 02 Apr 2022
Revision: 05 Oct 2022
Accepted: 08 Oct 2022
ePublished: 27 Aug 2023
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