J Shahrekord Univ Med Sci. 2023;25(4): 184-188.
doi: 10.34172/jsums.785
  Abstract View: 72
  PDF Download: 81

Original Article

Repeated electroporation enhances the responsiveness to cisplatin-based intra-tumoral chemotherapy in murine breast cancer: revival of the electro-chemotherapy concept

Elham Raeisi 1,2 ORCID logo, Seyed MahmoudReza Aghamiri 3* ORCID logo, Negar Rahmatpour 3, Azin Bandi 3, Sedigheh Amini-Kafie 4 ORCID logo, Lluis M Mir 5,6 ORCID logo

1 Clinical Biochemistry Research Center, Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Department of Medical Physics and Radiology Technology, Paramedical Faculty, Shahrekord University of Medical Sciences, Shahrekord, Iran
3 Medical Radiation Engineering, Shahid Beheshti University, Tehran, Iran
4 Department of Immunohematology, Research Center of Iranian Blood Transfusion Organization (IBTO), Tehran, Iran
5 CNRS, Orsay, Laboratoire de Vectorologie et Therapeutiques Anticancereuses, UMR 8203, 91405 Orsay Cedex, France
6 Institute Gustave Roussy, Laboratoire de Vectorologie et Therapeutiques Anticancereuses, UMR 8203, 114 rue E. Vaillant, 94805 Villejuif Cedex, France
*Corresponding Author: Seyed MahmoudReza Aghamiri, Email: smr-aghamiri@sbu.ac.ir


Background and aims: Electroporation demonstrated certain modulable actions on tumoral cell membrane permeability to increase the intracellular bioavailability of chemotherapeutic drugs. The current in vivo study aimed to investigate the synergic effect of concomitant electroporation application to the intratumoral administration of cisplatin on murine invasive ductal adenocarcinoma breast cancer.

Methods: The fragments of the extracted tumor were implanted subcutaneously in healthy female Balb/C mice. Having reached the determined tumoral volume, the mice were randomly divided into five groups, including control, intratumoral cisplatin injection, tumoral electroporation application, electrochemotherapy (ECT), and double course ECT. The normalized tumoral volume and the inhibition ratios were calculated during a 30-day follow-up period. The data were tested by ANONA, and a statistically significant level was set at P<0.05.

Results: The inhibition ratio was significantly different between the intra-tumoral cisplatin administration and tumoral electroporation application groups compared to the control group (P<0.05). ECT displayed superior results in comparison to the two later groups (P<0.05). The double-course ECT group even represented a significant difference compared to the ECT group (P<0.05).

Conclusion: Concomitant ECT to the cisplatin intratumoral administration indicated contributive anti-tumoral impacts in an in vivo murine model of invasive ductal adenocarcinoma breast cancer. ECT promises further applications to overcome the occurrence of therapeutic resistance to chemotherapeutic drugs.

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Abstract View: 73

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Submitted: 05 Sep 2022
Revision: 04 Mar 2023
Accepted: 04 Mar 2023
ePublished: 24 Oct 2023
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