Logo-jskums
J Shahrekord Univ Med Sci. 2024;26(2): 67-72.
doi: 10.34172/jsums.894
  Abstract View: 15
  PDF Download: 15

Original Article

The effect of a period of detraining followed by resistance training on fibrosis, angiogenesis, and cardiac dimensions of male Wistar rats

Masome Nobahar 1 ORCID logo, Fatemeh Ahmadi 1* ORCID logo, Shadmehr Mirdar Harijani 2 ORCID logo

1 Department of Physical Education and Sports Sciences, Tehran Payame Noor University, Tehran, Iran
2 Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, University of Mazandaran, Babolsar, Iran
*Corresponding Author: Fatemeh Ahmadi, Email: f.ahmadi@pnu.ac.ir

Abstract

Background and aims: Resistance training is associated with certain cardiovascular adaptations. However, a lack of exercise may affect it. Thus, the aim of this study was to investigate the effect of a period of detraining followed by resistance training on the fibrosis, angiogenesis, and cardiac dimensions of male Wistar rats.

Methods: In this experimental study, 20 male Wistar rats at the age of five weeks were randomly divided into control, training, control+detraining, and training+detraining groups. The control (8 weeks) and control+detraining (11 weeks) groups were placed in their respective cages with 24-hour free access to food and water and did not exercise for eight weeks. The resistance training+detraining and resistance training groups performed eight weeks of the resistance training protocol. The resistance training+detraining group did not do any type of training after the training period of 3 weeks. The results were analyzed by SPSS version 18.

Results: In terms of fibrosis, there was a significant difference between the control and control+detraining groups (P=0.001), between control and training groups (P=0.001), and between control+detraining and training+detraining groups (P=0.001). In addition, a significant difference was found between the training and training+detraining groups in terms of fibrosis (P=0.001). In terms of angiogenesis, a significant difference was observed between the control and training groups (P=0.001) and between the training and training+detraining groups (P=0.007).

Conclusion: Resistance training could reduce fibrosis and increase cardiac angiogenesis in rats. Based on the findings, fibrosis increased significantly in the detraining period compared to the active period, and angiogenesis was also reduced due to detraining.

First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 16

Your browser does not support the canvas element.


PDF Download: 15

Your browser does not support the canvas element.

Submitted: 19 Jun 2023
Accepted: 29 Oct 2023
ePublished: 27 May 2024
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)