Shahrekord University of Medical Sciences Journal of Shahrekord University of Medical Sciences 2717-0071 22 4 2020 12 29 Neurofilament heavy chain gene polymorphism and risk of multiple sclerosis 155 158 10.34172/jsums.2020.25 EN Elham Ghorbani Jazar https://orcid.org/0000-0002-1294-2594 Seyedeh Parisa Chavoshi Tarzjani https://orcid.org/0000-0001-6374-3686 Zahra Sadeghi https://orcid.org/0000-0002-0769-4506 Shekoofe Alaie https://orcid.org/0000-0002-8380-8069 Seyed Abolhassan Shahzadeh Fazeli https://orcid.org/0000-0002-0720-2954 Journal Article 10.34172/jsums.2020.25 2020 01 12 2020 06 01 Multiple sclerosis (MS) is a chronic disease characterized by degeneration of the central nervous system (CNS). High levels of Neurofilament heavy chain (NEFH) in cerebrospinal fluid (CSF) is associated with MS. 40 MS patients and 40 controls genotyped by polymerase chain reaction (PCR) and Sanger sequencing. Genotypic and allelic distributions were compared between cases and controls. Fisher test was used to estimate the risk of MS associated with genotypes. We showed that NEFH, 1084-244G>A gene polymorphism, has no significant association with the susceptibility or severity of MS in Iranian patients (P = 0.737). Further prospective studies are required for confirmation.