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J Shahrekord Univ Med Sci. 2022;24(4): 155-162.
doi: 10.34172/jsums.2022.26
  Abstract View: 22
  PDF Download: 24

Original Article

Comparison of the effect of polyethylene glycol 40% and fig syrups on the treatment of chronic functional constipation in children: A randomized clinical trial

Narges Maleki 1 ORCID logo, Karamali Kasiri 2* ORCID logo, Mohammad Reza Malek-Ahmadi 2 ORCID logo, Fatemeh Deris 1 ORCID logo

1 Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Department of Pediatrics, Shahrekord University of Medical Sciences, Shahrekord, Iran
Corresponding Author: Karamali Kasiri, Department of Pediatrics, Shahrekord University of Medical Sciences, Shahrekord, Iran Email: kasiri207@yahoo.com

Abstract

Background and aims: None of the available constipation treatments for children are completely successful. Therefore, the present study aimed to evaluate the effect of the polyethylene glycol (PEG) solution 40% and fig syrup on the treatment of chronic constipation in children.

Methods: In this double-blind clinical trial, 120 patients with chronic functional constipation were selected and divided into two groups. The first group received 5 mL of fig syrup without senna 3 times daily, and the second group took PEG 40% syrup at 1 mL/kg of body weight per day (the dose was adjustable according to the patient’s condition and need). At weeks 0, 2, 4, and 6, a checklist containing questions about children’s constipation was completed by the researcher, and the data were analyzed by SPSS version 24.

Results: Changes in the frequency of abdominal pain at fourth times 0, 2, 4, and 6 weeks demonstrated statistically significant differences between the two groups (P=0.044), and it was significantly lower the in PEG group; however, the defecation was not statistically significant (P=0.902). After six weeks, the frequency of painful defecation, difficult defecation straining during defecation, and fear of defecation was significantly lower in the group given PEG syrup compared to the fig syrup-receiving group (P=0.001).

Conclusion: Overall, PEG syrup was significantly effective in treating chronic functional constipation in children compared to the fig syrup.

Keywords: Constipation, Polyethylene glycol, Children, Fig syrup
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Submitted: 07 Feb 2021
Revision: 05 Feb 2022
Accepted: 05 Feb 2022
ePublished: 08 Sep 2022
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