Journal of Shahrekord University of Medical Sciences
J Shahrekord Univ Med Sci. 2020;22(1): 6-10.
doi: 10.34172/jsums.2020.02
  Abstract View: 65

Original Article

The frequency of cytogenetic abnormalities in idiopathic oligospermia and azoospermia infertile men in Chaharmahal and Bakhtiari province: a cross-sectional study

Hamideh Jafari- Ghahfarrokhi 1 ORCID logo, Delnya Gholami 1 ORCID logo, Mohammad Rajaie Esfahani 2 ORCID logo, Hossein Teimori 1 * ORCID logo

1 Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran.
2 Department of Urology, Shahrekord University of Medical Sciences, Shahrekord, Iran.
*Corresponding Author: Dr. Hossein Teimori, Associate Professor, Head of Medical Genetics, Shahrekord University of Medical Sciences, Tel: +98-38-33346691 Email: hteimori@skums.ac.ir

Abstract

Background and aims: Infertility is one of the main health issues in families worldwide. In addition, there is a complex correlation between genetics and infertility and chromosomal abnormalities are found in 8% of infertile males. The aim of this study was to determine the frequency of cytogenetic abnormalities among idiopathic oligospermia and azoospermia infertile men who were treated in Chaharmahal and Bakhtiari province.

Methods: In this cross-sectional study, the records of a total of 100 participants were evaluated retrospectively. The patients who were under careful physical and para-clinical (i.e., hormonal, ultrasound, and spermiogeram) examinations were enrolled in the study. Chromosomal analysis was carried out on the cultures of peripheral blood lymphocytes by Giemsa (G) banding. Eventually, 10 well-spread metaphases were analyzed by G-banding.

Result: The chromosome abnormality frequency, the numerical type, and the structural type were 13%, 3%, and 10%, respectively. Among patients with azoospermia, two cases had Klinefelter syndrome with karyotype.

Conclusion: This study demonstrated that structural abnormalities are more prevalent than numerical abnormalities in infertile men who were treated in Chaharmahal and Bakhtiari province. This indicates the importance of cytogenetic examination and the relevance of its achievements to the patient’s management in infertility clinics. Therefore, the cytogenetic test is proposed for infertile men, in particular in those who endure azoospermia.

Keywords: Chromosomal abnormality, Male infertility, Oligospermia, Azoospermia
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Submitted: 15 May 2019
Accepted: 13 Jul 2019
ePublished: 28 Feb 2020
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