Logo-jskums
J Shahrekord Univ Med Sci. 2021;23(4): 179-183.
doi: 10.34172/jsums.2021.30
  Abstract View: 48
  PDF Download: 32

Original Article

The effect of moderate-intensity aerobic training on serum levels of TNF-α and IL-6 in rats undergoing radiotherapy

Mina Khaleghi 1 ORCID logo, Khalid Mohamadzadeh Salamat 1* ORCID logo, Mohammad Parastesh 2 ORCID logo, Kamal Azizbeigi 1 ORCID logo, Mohammad Reza Bayatiani 3 ORCID logo

1 Department of Exercise Physiology, Islamic Azad University, Sanandj Branch, Sanandaj , Iran
2 Department of Sports Physiology and Pathology, Faculty of Sport Sciences, Arak University, Arak, Iran
3 Department of Radiotherapy and Medical Physics, Faculty of Para Medicine, Arak University of Medical Sciences and Khansari Hospital, Arak, Iran
*Corresponding Author: Khalid Mohamadzadeh Salamat, Department of Exercise Physiology, Islamic Azad University, Sanandj Branch, Sanandaj , Iran. Tel: 09187635573, Email: kh.mohamadzadeh@gmail.com

Abstract

Background and aims: One of the main potential problems of radiotherapy (RT) in breast cancer is the increase in treatment-related inflammation. This study aimed to investigate the effect of eight weeks of moderate-intensity aerobic training (AT) on serum levels of tumor necrosis factor α (TNF-α) and interleukin-6 (IL-6) in rats undergoing RT.

Materials and Methods: In this experimental study, 32 male rats were randomly divided into four groups of eight members including (1) healthy control (C), (2) AT, (3) RT, and (4) AT + RT groups. Rats were first anesthetized with ketamine-xylazine solution (K, 60-90 kg/mg; Z, 6-10 kg/mg) and then located on a Plexiglas plate with a thickness of 1 cm. Photon beam RT was performed using X-rays with a dose of 11 Gy from an Elekta compact linear accelerator (Elekta Compact 6-MV China). AT program was performed for eight weeks, five days a week, and one session a day for 60 minutes (70-75% of VO2max). Afterwards, one-way ANOVA was run to examine the research variables.

Results: According to the results, TNF-α was significantly higher in the RT group compared to the C group (P=0.003), whereas IL-6 levels were significantly lower in the AT + RT group compared to the RT group (P=0.001) and the C group (P=0.027). Further, the levels of this cytokine were significantly lower in the AT group compared to the RT group (P=0.006) and similarly in the RT group compared to the C group (P=0.03).

Conclusion: RT led to an increase in pro-inflammatory cytokines; however, performing AT could only significantly reduce the IL-6 levels.


Keywords: Radiotherapy, Aerobic exercise, TNF-α, IL-6

First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 48

Your browser does not support the canvas element.


PDF Download: 32

Your browser does not support the canvas element.

Submitted: 27 Jun 2021
Accepted: 29 Sep 2021
ePublished: 06 Dec 2021
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)