Logo-jskums
J Shahrekord Univ Med Sci. 2022;24(4): 168-173.
doi: 10.34172/jsums.2022.28
  Abstract View: 19
  PDF Download: 24

Original Article

Investigation of the effect of early and late breast milk enrichment on growth parameters in preterm infants: A randomized clinical trial

Majid Hamidi 1 ORCID logo, Nabiollah Asadpour 2* ORCID logo, Roya Choopani 2 ORCID logo

1 Assistant Professor of Neonatal-Perinatal Medicine, Department of Pediatrics, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Assistant Professor of Pediatric Cardiology, Department of Pediatrics, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
Corresponding Author:Nabiolah Asadpour, Shahrekord University of Medical Sciences, Shahrekord, Iran. Tel: +989131846081, Email: dr.asad50@gmail.com

Abstract

Background and aims: This study aimed to investigate and compare the effect of early and late breast milk fortification on growth parameters in preterm infants.

Methods: In this clinical trial, 90 preterm infants (28-32 weeks) admitted to the neonatal intensive care unit (NICU) of Hajar Hospital in Shahrekord, Iran were randomly divided into three groups. The fortification was performed when the milk intake reached 30 (group A), 70 (group B), and 100 cc/kg (group C). The height, weight, and head circumference of newborns were measured at the beginning of birth and 4 weeks after the birth. The incidence of sepsis and necrotizing enterocolitis, and milk tolerance were investigated as well. All analyses were conducted with Stata software, and P values<0.05 were considered statistically significant.

Results: The value changes in the height, weight, and head circumference in all three groups at 4 weeks were significant (P<0.001). The mean weight changes in the A, B, and C groups were 727.33±163.85, 947.33±155.38, and 808.66±168.82, indicating a statistically significant difference (P<0.001). Further, the mean change of weight after 4 weeks showed statistically significant differences (P<0.001) among the A, B, and C groups. The weight gain in the B group was significantly higher than that of the A and C groups (P<0.05); however, no significant difference was observed in the mean weight gain between the A and C groups (P=0.264).

Conclusion: The breast milk fortification when the milk intake reached 70 cc/kg had better efficiency on neonatal weight gain compared with the early and delayed fortification.

Keywords: Preterm infant, Colostrum, Milk fortifier
First Name
 
Last Name
 
Email Address
 
Comments
 
Security code


Abstract View: 19

Your browser does not support the canvas element.


PDF Download: 24

Your browser does not support the canvas element.

Submitted: 17 Jul 2021
Revision: 10 Apr 2022
Accepted: 10 Apr 2022
ePublished: 08 Sep 2022
EndNote EndNote

(Enw Format - Win & Mac)

BibTeX BibTeX

(Bib Format - Win & Mac)

Bookends Bookends

(Ris Format - Mac only)

EasyBib EasyBib

(Ris Format - Win & Mac)

Medlars Medlars

(Txt Format - Win & Mac)

Mendeley Web Mendeley Web
Mendeley Mendeley

(Ris Format - Win & Mac)

Papers Papers

(Ris Format - Win & Mac)

ProCite ProCite

(Ris Format - Win & Mac)

Reference Manager Reference Manager

(Ris Format - Win only)

Refworks Refworks

(Refworks Format - Win & Mac)

Zotero Zotero

(Ris Format - Firefox Plugin)