J Shahrekord Univ Med Sci. 2022;24(2): 78-83.
doi: 10.34172/jsums.2022.13
  Abstract View: 74
  PDF Download: 61

Original Article

Effect of aqueous extract of fig fruit (Ficus Carica) on wound healing in albino rabbits

Zahra Mokhtari Zarch 1 ORCID logo, Elham Salehi 1* ORCID logo, Majid Morovati-Sharifabad 1 ORCID logo, Amin Paidar Ardakani 2 ORCID logo, Mohammad Saeed Heydarnejad 3 ORCID logo

1 Department of Basic Sciences, Faculty of Veterinary Medicine, Ardakan University, Ardakan, Iran
2 Department of Clinical Sciences, Faculty of Veterinary Medicine, Ardakan University, Ardakan, Iran
3 Department of Animal Sciences, Faculty of Basic Sciences, Shahrekord University, Shahrekord, Iran


Background and aims: Skin ulcers are caused by various reasons such as physical, chemical, and biological damages. Wound healing has long been considered one of the most important issues in surgery. Extensive research has been employed in this field and various chemical, herbal, homeopathic, and physical methods such as laser therapy have been used for treatment. Nowadays, wound healing is one of the most important aims of medical science. Furthermore, people prefer to use natural drugs because of fewer side effects. Therefore, the present study was designed considering these issues.

Methods: For this study, 6 albino rabbits with an average weight of 3 kg were purchased. After preparing the rabbits, two pairs of full-thickness wounds were created in a completely round shape with a diameter of almost 6.30 mm on both sides of the spine in two anterior and posterior parts at a distance of 3 cm from the midline of the body. The animals were divided into 2 groups of 3 rabbits, including 1 experimental group and 1 control group. The wounds of the experimental group were treated with fig fruit extract while the wounds of the control group received no treatment. The wounds were macroscopically examined at 4, 7, 12, 16, and 20 days after surgery.

Results: The results of t-test showed a significant difference (P<0.05) among the groups on all days. Meanwhile, the average wound area significantly decreased in the group which was treated with the extract of fig fruit.

Conclusion: This study showed that fig fruit extract contains phenolic compounds with antioxidant, antimicrobial, and anti-inflammatory properties which can accelerate the wound healing process.

Keywords: Fig fruit extract, Skin wound, Albino rabbit, Surgery
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Submitted: 22 Aug 2021
Revision: 17 Jan 2022
Accepted: 17 Jan 2022
ePublished: 02 Jun 2022
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