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J Shahrekord Univ Med Sci. 2022;24(4): 189-195.
doi: 10.34172/jsums.2022.31
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Original Article

The effect of eight-week resistance training and consumption of grape seed nanoparticles on mitochondrial biogenesis of heart tissue in the myocardial infarction model

Ebrahim Khaki 1 ORCID logo, Khosro Jalali Dehkordi 1* ORCID logo, Farzaneh Taghian 1 ORCID logo, Seyed Ali Hoseini 2 ORCID logo

1 Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran
2 Department of Physical Education and Sport Sciences, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
Corresponding Author: Khosro Jalali Dehkordi, Department of Sports Physiology, Faculty of Sports Sciences, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran. Postcode: 81551-39998. Tel:+989131854997, Fax:+98031-353- 54135, Email: khosro jalali@gmail.com

Abstract

Background and aims: The consumption of grape seed nanoparticles extract can control cardiovascular risk factors. Exercise plays a protective role against cardiovascular disease. Therefore, the aim of the present study was to investigate the effect of eight-week resistance training (RT) and the use of grape seed nanoparticles on mitochondrial biogenesis of heart tissue in myocardial infarction (MI) models.

Methods: In this experimental study, 25 rats were randomly divided into five groups including (1) control (C), (2) MI, (3) MI+RT, (4) MI+grape seed, and (5) MI+RT+grape seed. MI was induced by subcutaneous injection of isoprenaline (85 mg/kg). Grape seed nanoparticles were daily administered at a dose of 150 mg/kg for 8 weeks, and RT was performed 5 days a week. Finally, data were analyzed using the one-way analysis of variance (ANOVA) and Tukey’s post hoc tests (P≤0.05).

Results: MI models showed decreased expression of PGC-1α, PPARγ, and UCP-1 genes in cardiac tissue (P=0.001). However, RT combined with the use of grape seed nanoparticles had a significant effect on increasing the expression of PGC-1α (P=0.001), PPARγ (P=0.002), and UCP-1 (P=0.003) genes in the heart tissue of MI model mice.

Conclusion: The consumption of grape seed nanoparticles along with RT has more effects on improving the expression of PGC-1α, PPARγ, and UCP-1 genes in MI than either alone. Therefore, the use of grape seed nanoparticles together with RT is recommended in case of MI.

Keywords: Resistance Training, Grape seed, PGC-1α, PPARγ, UCP-1, Myocardial infarction
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Submitted: 05 Apr 2022
Revision: 29 Jun 2022
Accepted: 29 Jun 2022
ePublished: 08 Sep 2022
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