J Shahrekord Univ Med Sci. 2019;21(6): 276-279.
doi: 10.34172/jsums.2019.48
  Abstract View: 839
  PDF Download: 229

Original Article

Prediction of probable impact of miR-34a and miR-215 on differentiation of naive CD4+ T cells to Th17 cells in multiple sclerosis

Nooshin Ghadiri 1,2 ORCID logo, Aref Hoseini 3, Kamran Ghaedi 3,2, Negar Alsadat Emamnia 2, Mazdak Ganjalikhani-Hakemi 4* ORCID logo, Parnian Navabi 4, Hedyatollah Shirzad 1, Mohammad Hossein Nasr-Esfahani 2

1 Department of Immunology, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
2 Department of Cellular Biotechnology, Cell Science Research Center, ACECR, Royan Institute for Biotechnology, Isfahan, Iran
3 Department of Biology, Faculty of Sciences, University of Isfahan, Isfahan, Iran
4 Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
*Corresponding Author: *Corresponding Author: Mazdak Ganjalikhani-Hakemi, PhD., Associate Professor in Department of Immunology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran, Tel: +98-31-37929082, E-mail: , Email: mghakemi@med.mui.ac.ir


Background and aims: miRNAs, as a class of non-coding RNAs, take part in different cellular processes. Dysregulation of different miRNAs has been reported in numerous disorders to date. Multiple sclerosis (MS) is an autoimmune disease with high prevalence in Iran and Th17 cells play an important role in its pathogenesis. In the current study, we aimed to predict the possible role of miR-34a and miR-215 in the process of controlling Th17 differentiation, and hence, their possible impact on the onset and progression of MS.

Methods: We investigated probable interactions of miRNAs and genes that participate in Th17 cells differentiation using miRwalk database as an integrative one which utilizes 10 different algorithms to predict miRNA-mRNA interaction.

Results: Based on our findings, miR-34a and miR-215 were predicted to have a potential role in the induction of Th17 cells differentiation.

Conclusion: Conclusively, miR-34a and miR-215 may up-regulate Th17 cells of MS patients. Since bioinformatics data have shown that these miRNAs suppress negative regulatory genes in Th17 cells differentiation, we suppose that down-regulation of these miRNAs could ameliorate MS symptoms. Therefore, several therapeutic approaches may be considered for these miRNAs besides their application as valuable prognostic/diagnostic biomarkers in detection of various stages of MS.

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Submitted: 20 Nov 2018
Accepted: 28 Dec 2018
ePublished: 28 Dec 2018
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